Virus mutation genomics and COVID-19 vaccine immunology.

We have evolved in great evolutionary peril that we can literally see unravelling genetically in the protein sequence imaging of the Corona Virus mutations. Evolution is not progress but natural selection. James Watson unravelled the double helix and telling us about genetic mutation without which knowledge COVID would remain an enigma.

Our gut microbiomes help metabolize our dietary nutrients through atleast 48 pathways. Micro-organisms make up one to three percent of our body mass. There are over 2000 species of gut bacteria. Immunology deals with our microbiomes and the vaccines prepare our immune system to fight the virus, with a learning and a nudge so that the dendritic cells of the adaptive immune system (among mononuclear white blood cells) can prepare the antibodies and T cells (like CD4) based on the antigens absorbed from the proteins of the spikes of the corona virus. The spikes are literally sugar coated and remain camouflaged till they connect to the protein signalling receptor cells in the lungs, heart, or brain through the so called receptor binding domain material of the spikes.

The Omicron subvariants descendants have evolved from the original extinct SARS-COV-2 COVID-19 virus may mutate into a dominant version that escapes antigen (virus spike peptide particles) absorption by the Major Histocompatibility Complex or the Human Leukocyte Antigen (HLA) protein receptors on the surface of the lymphocyte (white blood cells). The peptide particles of COVID-19 mutated spike proteins may not present themselves as antigenic epitope to the MHC receptors or may not be detected.

“Any substance that causes the body to make an immune response against that substance. Antigens include toxins, chemicals, bacteria, viruses, or other substances that come from outside the body.” An epitope is the recognised part of the foreign antigenic protein. The vaccine teaches the adaptive immune system about the trojan corona spike protein antigens. The short point is that all allergies are not infections of alien micro-organisms but all infections are allergies as seen by the innate immune system because our bodies have trillions of bacteria and virus floating around inside us.

The Omicron subvariants descendants have evolved from the original extinct SARS-COV-2 COVID-19 virus may mutate into a dominant version that escapes antigen (virus spike peptide particles) absorption by the Major Histocompatibility Complex or the Human Leukocyte Antigen (HLA) protein receptors on the surface of the lymphocyte (white blood cells). The peptide particles of COVID-19 mutated spike proteins may not present themselves as antigen to the MHC receptors or may not be detected.

The moral hazard of not taking the vaccine because when you are wishfully depending on denying the danger because it won’t come to you, and it is the vaccine that will prepare you for the danger when you meet a vector and more important you become a vector yourself. The ethics of denying science because you doubt data based on trials and bank on hearsay is the main reason this virus will mutate.

All dogma is a type of neurosis, because each rules out the other based on the fear of some non-existent notion. Ancient ideas are wrong, orthodoxy is not science. Quantum mechanics shows science does not need a human observer to happen. What we learn from quantum physics is that learning itself is experiential. The world and our understanding of it is granular, relative, and not continuous and in sameness, what we impose on the world, our categories are tinted by our everyday particular experience. The archaeology of our knowledge tells us about knowledge based on our experience of everything around us that influences our ideas, our familiarity about who we are and what we consume.

“When [Scott] Atran claimed that folk biology mirrors professional biology, he was criticized because folk categories like “vegetable” and “pet” match no Linnaean taxon. He replies that they are artifacts. Not only are they defined by the needs they serve (savory, succulent food; tractable companions), but they are, quite literally, human products. Millennia of selective breeding have created corn out of a grass and carrots out of a root. One has only to imagine packs of French poodles roaming the primeval forests to realize that most pets are human creations, too”, writes cognitive psychologist Steven Pincker.

Nature selects phylogenetic relationships between organisms through bio-geographic and genealogical distribution over generations, organisms are not necessarily related by human observed morphology and universality. See https://www.nature.com/articles/s42003-022-03482-x

See how Electric Fish Genomes Reveal How Evolution Repeats Itself at https://www.quantamagazine.org/electric-fish-genomes-reveal-how-evolution-repeats-itself-20220822/

“The rabbits that we see are shadows of the perfect ‘idea’ of rabbit, the ideal, essential, Platonic rabbit, hanging somewhere out in conceptual space along with all the perfect forms of geometry. Flesh-and-blood rabbits may vary, but their variations are always to be seen as flawed deviations from the ideal essence of rabbit. How desperately unevolutionary that picture is! The Platonist regards any change in rabbits as a messy departure from the essential rabbit, and there will always be resistance to change – as if all real rabbits were tethered by an invisible elastic cord to the Essential Rabbit in the Sky”, writes evolutionary biologist Richard Dawkins.

We have been to the moon before we had a touch screen device or we knew about CRISPR gene editing, the advance of technology has nothing to do with our beliefs, fears and biases. 

DNA: The secret of life. From folk biology to molecular biology.

See for reference:

https://www.nature.com/articles/d41586-021-02039-y

https://www.nature.com/scitable/topicpage/discovery-of-dna-structure-and-function-watson-397/

https://www.immunology.org/public-information/bitesized-immunology/cells/dendritic-cells

https://www.nature.com/articles/s42003-022-03482-x

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.science.org/doi/10.1126/sciadv.abn8016

https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body#:~:text=The%20human%20body%20contains%20trillions,vital%20role%20in%20human%20health.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.