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Virus mutation genomics and COVID-19 vaccine immunology.

Nature selects phylogenetic relationships between organisms through bio-geographic and genealogical distribution over generations, organisms are not necessarily related by human observed morphology.

We have evolved in great peril and this is once again an evolutionary peril that we can literally see unravelling genetically in the protein sequence imaging of the Corona Virus mutations. Evolution is not progress but natural selection.

We owe James Watson a big thank you for unravelling the double helix and telling us about genetic mutation without which knowledge COVID would remain an enigma. See the cover of his book in the featured image on this post.

This earth is a gigantic wet waste composting process and animals and plants are just biding their time against microorganisms that are inside their bodies, and actually our stomachs are composting bags…working with the help of our gut microbiomes. Our microbiomes help metabolize our dietary nutrients through atleast 48 pathways. Micro-organisms make up one to three percent of our body mass.


Immunology deals with our microbiomes and the vaccines prepare our immune system to fight the virus, with a learning and a nudge so that the dendritic cells of the adaptive immune system (among mononuclear white blood cells) can prepare the antibodies and T cells (like CD4) based on the antigens absorbed from the proteins of the spikes of the corona virus. The spikes are literally sugar coated and remain camouflaged till they connect to the protein signalling receptor cells in the lungs, heart, or brain through the so called receptor binding domain material of the spikes.

The vaccine teaches the adaptive immune system about the trojan corona spike proteins. The short point is that all allergies are not infections of alien micro-organisms but all infections are allergies as seen by the innate immune system because our bodies have trillions of bacteria and virus floating around inside us.

The moral hazard of not taking the vaccine because when you are wishfully depending on denying the danger because it won’t come to you, and it is the vaccine that will prepare you for the danger when you meet a vector and more important you become a vector yourself. The ethics of denying science because you doubt data based on trials and bank on hearsay is the main reason this virus will mutate.

All dogma is a type of neurosis, because each rules out the other based on the fear of some non-existent notion. In the words of James Watson who wrote in his book DNA, “Those of us who feel no need for a moral code written down in an ancient tome have, in my opinion, recourse to an innate moral intuition long ago shaped by natural selection promoting social cohesion in groups of our ancestors. The rift between tradition and secularism first opened by the Enlightenment has, in more or less its present form, dictated biology’s place in society since the Victorian period. There are those who will continue to believe humans are creations of God, whose will we must serve, while others will continue to embrace the empirical evidence indicating that humans are the product of many millions of generations of evolutionary change.”

Ancient ideas are wrong, orthodoxy is not science.
“When [Scott] Atran claimed that folk biology mirrors professional biology, he was criticized because folk categories like “vegetable” and “pet” match no Linnaean taxon. He replies that they are artifacts. Not only are they defined by the needs they serve (savory, succulent food; tractable companions), but they are, quite literally, human products. Millennia of selective breeding have created corn out of a grass and carrots out of a root. One has only to imagine packs of French poodles roaming the primeval forests to realize that most pets are human creations, too”. said Steven Pincker

Nature selects phylogenetic relationships between organisms through bio-geographic and genealogical distribution over generations, organisms are not necessarily related by human observed morphology and universality. See https://www.nature.com/articles/s42003-022-03482-x

“The rabbits that we see are shadows of the perfect ‘idea’ of rabbit, the ideal, essential, Platonic rabbit, hanging somewhere out in conceptual space along with all the perfect forms of geometry. Flesh-and-blood rabbits may vary, but their variations are always to be seen as flawed deviations from the ideal essence of rabbit. How desperately unevolutionary that picture is! The Platonist regards any change in rabbits as a messy departure from the essential rabbit, and there will always be resistance to change – as if all real rabbits were tethered by an invisible elastic cord to the Essential Rabbit in the Sky”, writes evolutionary biologist Richard Dawkins.

We have been to the moon before we had a touch screen device or we knew about CRISPR gene editing, the advance of technology has nothing to do with our beliefs, fears and biases. 

DNA: The secret of life. From folk biology to molecular biology.

See for reference:

https://www.nature.com/articles/d41586-021-02039-y

https://www.nature.com/scitable/topicpage/discovery-of-dna-structure-and-function-watson-397/

https://www.immunology.org/public-information/bitesized-immunology/cells/dendritic-cells

https://www.nature.com/articles/s42003-022-03482-x

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor.

https://www.science.org/doi/10.1126/sciadv.abn8016

https://www.nih.gov/news-events/news-releases/nih-human-microbiome-project-defines-normal-bacterial-makeup-body#:~:text=The%20human%20body%20contains%20trillions,vital%20role%20in%20human%20health.

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